A Very-Low Calorie Diet Can Cause Remission of Diabetes Mellitus and Hypertriglyceridemia in Familial Partial Lipodystrophy

Foss-Freitas M. C., Besci Ö., Meral R., Neidert A., Chenevert T. L., Oral E. A., ...Daha Fazla

OBESITY FACTS, cilt.17, sa.1, ss.103-108, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1159/000533992
  • Dergi Adı: OBESITY FACTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, ABI/INFORM, Food Science & Technology Abstracts, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.103-108
  • Anahtar Kelimeler: Body weight, diabetes, lipids, diet, female sexual function
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

There is no strong evidence that any specific diet is the preferred treatment for lipodystrophy syndromes. Here we remark on the benefits of a very-low calorie diet (VLCD) in a patient with familial partial lipodystrophy type 2 (FPLD2). A 38-year-old female diagnosed with FPLD2, with a history of multiple comorbidities, underwent 16 weeks of VLCD with a short-term goal of improving her metabolic state rapidly to achieve pregnancy by in-vitro fertilization (IVF). We observed a reduction of 12.3kg in body weight and 1.4% in HbA1c. The decrease in the area under the curves of insulin (-33.2%), triglycerides (-40.7%), and free fatty acids (-34%) were very remarkable. Total body fat was reduced by 16%, and liver fat by 80%. Her egg retrieval rate and quality during IVF were far superior to past hyperstimulation. Our data encourage the use of this medical approach for other patients with similar metabolic and reproductive abnormalities due to adipose tissue insufficiency.