Multifunctional, histidine-tagged polymers: antibody conjugation and signal amplification
CHEMICAL COMMUNICATIONS, cilt.56, sa.89, ss.13856-13859, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 89
- Basım Tarihi: 2020
- Doi Numarası: 10.1039/d0cc04591h
- Dergi Adı: CHEMICAL COMMUNICATIONS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Communication Abstracts, EMBASE, MEDLINE, DIALNET
- Sayfa Sayıları: ss.13856-13859
- Dokuz Eylül Üniversitesi Adresli: Hayır
Özet
A polymer scaffold, with multiple reactive centres, was synthesised by RAFT polymerisation and conjugated to the antibody herceptin. A hexahistidine RAFT agent enabled the rapid and simple purification of polymer-protein conjugates, while the tetrazine conjugation strategy allows myriad cargos to be attached and amplified.