Multifunctional, histidine-tagged polymers: antibody conjugation and signal amplification


Zhang Y., Gambardella A., ÜÇÜNCÜ M., Geng J., Clavadetscher J., Bradley M., ...Daha Fazla

CHEMICAL COMMUNICATIONS, cilt.56, sa.89, ss.13856-13859, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 89
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1039/d0cc04591h
  • Dergi Adı: CHEMICAL COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Communication Abstracts, EMBASE, MEDLINE, DIALNET
  • Sayfa Sayıları: ss.13856-13859
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

A polymer scaffold, with multiple reactive centres, was synthesised by RAFT polymerisation and conjugated to the antibody herceptin. A hexahistidine RAFT agent enabled the rapid and simple purification of polymer-protein conjugates, while the tetrazine conjugation strategy allows myriad cargos to be attached and amplified.