Undifferentiated Laryngeal Carcinoma with Pagetoid Spread

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SARIOĞLU S., DOĞAN E., Sahin Y., Uzun E., BEKİŞ R., ADA E., ...More

HEAD & NECK PATHOLOGY, vol.10, no.2, pp.252-255, 2016 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1007/s12105-015-0648-7
  • Journal Name: HEAD & NECK PATHOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.252-255
  • Keywords: Larynx, Undifferentiated carcinoma, Pagetoid spread, Aggressive behavior, ORAL-MUCOSA, DISEASE
  • Dokuz Eylül University Affiliated: Yes


Pagetoid spread, is used to define intraepithelial spread of cancer cells, when a massive carcinoma is identified beneath the basal membrane. There are only few reports of pagetoid spread at the head and neck region. Herein a 74 year old male patient with bilateral transglottic laryngeal high grade malignant epithelial tumor with pagetoid spread is presented. The tumor was located at the submucosa and there was spread of the CK7 and CK19 positive tumor cells into the non neoplastic mucosa, which was CK5/6 positive, sparing the basement membrane, creating a typical pagetoid pattern. Radiographic and positron emission tomography scan examination of the patient was unremarkable at presentation other than the laryngeal and neck lesions; but extensive systemic metastasis developed at 6 months following operation. To the best of our knowledge no epithelial malignancy with pagetoid spread was described at the larynx. Pagetoid spread may be a hallmark of very aggressive behavior in laryngeal carcinoma.