Bioorthogonal Swarming: In Situ Generation of Dendrimers
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol.142, no.52, pp.21615-21621, 2020 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 142 Issue: 52
- Publication Date: 2020
- Doi Number: 10.1021/jacs.0c07869
- Journal Name: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Applied Science & Technology Source, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Artic & Antarctic Regions, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Compendex, Computer & Applied Sciences, EMBASE, MEDLINE, DIALNET
- Page Numbers: pp.21615-21621
- Dokuz Eylül University Affiliated: No
Abstract
With the aid of bioorthogonal chemistry, we demonstrate the fabrication of synthetic dendrimers in situ around living cells. Using tetrazine dienophile and aminooxyl/hydrazide aldehyde chemistries, the density of functional groups on the dendrimers exponentially amplified intensities of fluorescent markers in antibody-targeted live cell imaging. This novel "swarming" approach highlights the power of bioorthogonal chemistry and provides a route to non-natural chemical structures on cells, paving the way for the generation of various artificial cellular nanostructures and scaffolds.