Urinary trypsin inhibitor present in fetal urine prevents intraamniotic meconium-induced intestinal damage in gastroschisis

OLGUNER M., HAKGÜDER F. G., Ates O., Caglar M., Ozer E., Akgur F. M.

JOURNAL OF PEDIATRIC SURGERY, cilt.41, sa.8, ss.1407-1412, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 8
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.jpedsurg.2006.04.016
  • Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1407-1412
  • Anahtar Kelimeler: gastroschisis, intestinal damage, urinary trypsin inhibitor, ALLANTOIC FLUID EXCHANGE, HUMAN NEONATAL URINE, IN-UTERO DEFECATION, AMNIOTIC-FLUID, DECREASED LEVELS, MODEL, INTERLEUKIN-8, ELASTASE, FETUS, MYELOMENINGOCELE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background/Purpose: Contact with amniotic fluid causes intestinal damage in gastroschisis, and intraammotic meconium has been shown to be responsible. Meconium has been shown to contain a significant amount of IL-8, which may be the responsible cytokine for harmful effects of meconium. Neonatal urine contains high amount of urinary trypsin inhibitor (UTI) compared with adult human urine. Urinary trypsin inhibitor has been shown to exert inhibitory effects on IL-8. Therefore, far from being destructive, presence of fetal urine in the amniotic fluid might be beneficial because human urine contains UTI. An experimental study has been performed to investigate whether presence of intraamniotic human urine (consequently UTI) besides meconium is beneficial on intestines of chick embryo with gastroschisis.