Urinary trypsin inhibitor present in fetal urine prevents intraamniotic meconium-induced intestinal damage in gastroschisis

OLGUNER M., HAKGÜDER F. G., Ates O., Caglar M., Ozer E., Akgur F. M.

JOURNAL OF PEDIATRIC SURGERY, vol.41, no.8, pp.1407-1412, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 8
  • Publication Date: 2006
  • Doi Number: 10.1016/j.jpedsurg.2006.04.016
  • Journal Name: JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1407-1412
  • Keywords: gastroschisis, intestinal damage, urinary trypsin inhibitor
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background/Purpose: Contact with amniotic fluid causes intestinal damage in gastroschisis, and intraammotic meconium has been shown to be responsible. Meconium has been shown to contain a significant amount of IL-8, which may be the responsible cytokine for harmful effects of meconium. Neonatal urine contains high amount of urinary trypsin inhibitor (UTI) compared with adult human urine. Urinary trypsin inhibitor has been shown to exert inhibitory effects on IL-8. Therefore, far from being destructive, presence of fetal urine in the amniotic fluid might be beneficial because human urine contains UTI. An experimental study has been performed to investigate whether presence of intraamniotic human urine (consequently UTI) besides meconium is beneficial on intestines of chick embryo with gastroschisis.