Alterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) serum levels in bipolar disorder: The role of lithium

Tunca, Zeliha; Ozerdem, Aysegul; Ceylan, Deniz; Yalcin, Yaprak; Can, Gunes; Resmi, Halil; AKAN, PINAR; ERGÖR, GÜL; AYDEMİR, ÖMER; Cengisiz, Cengiz; Doyurana, Kerim

doi:10.1016/j.jad.2014.05.012

Alterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) serum levels in bipolar disorder: The role of lithium

Tunca Z., Ozerdem A., Ceylan D., Yalcin Y., Can G., Resmi H., ...Daha Fazla

JOURNAL OF AFFECTIVE DISORDERS, cilt.166, ss.193-200, 2014 (SCI-Expanded, SSCI, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 166
Basım Tarihi: 2014
Doi Numarası: 10.1016/j.jad.2014.05.012
Dergi Adı: JOURNAL OF AFFECTIVE DISORDERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
Sayfa Sayıları: ss.193-200
Anahtar Kelimeler: BDNF (Bidill-derived neurotrophic factor), GDNF (glial cell line-derived neurotrophic factor), Bipolar disorder, Lithium, Valproate
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective: Brain-derived neurotrophic factor (BDNF) has been consistently reported to be decreased in mania or depression in bipolar disorders. Evidence suggests that Glial cell line-derived neurotrophic factor (GDNF) has a role in the pathogenesis of mood disorders. Whether GDNF and BDNF act in the same way across different episodes in bipolar disorders is unclear.