Alterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) serum levels in bipolar disorder: The role of lithium

Tunca, Zeliha; Ozerdem, Aysegul; Ceylan, Deniz; Yalcin, Yaprak; Can, Gunes; Resmi, Halil; AKAN, PINAR; ERGÖR, GÜL; AYDEMİR, ÖMER; Cengisiz, Cengiz; Doyurana, Kerim

doi:10.1016/j.jad.2014.05.012

Alterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) serum levels in bipolar disorder: The role of lithium

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Tunca Z., Ozerdem A., Ceylan D., Yalcin Y., Can G., Resmi H., ...More

JOURNAL OF AFFECTIVE DISORDERS, vol.166, pp.193-200, 2014 (SCI-Expanded)

Publication Type: Article / Article
Volume: 166
Publication Date: 2014
Doi Number: 10.1016/j.jad.2014.05.012
Journal Name: JOURNAL OF AFFECTIVE DISORDERS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
Page Numbers: pp.193-200
Keywords: BDNF (Bidill-derived neurotrophic factor), GDNF (glial cell line-derived neurotrophic factor), Bipolar disorder, Lithium, Valproate, MOOD DISORDERS, NEURONAL PLASTICITY, DECREASED LEVELS, RATING-SCALE, PLASMA BDNF, DEPRESSION, AGE, EXPRESSION, GLUTAMATE, MODEL
Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Brain-derived neurotrophic factor (BDNF) has been consistently reported to be decreased in mania or depression in bipolar disorders. Evidence suggests that Glial cell line-derived neurotrophic factor (GDNF) has a role in the pathogenesis of mood disorders. Whether GDNF and BDNF act in the same way across different episodes in bipolar disorders is unclear.