Akademik Veri Yönetim Sistemi
Anestezi Dergisi, cilt.15, sa.4, ss.223-227, 2007 (Scopus)
Objective: The aim of this study was to evaluate the analgesic effect and toxicity at spinal level when esmolol is administered intrathecally in rat. Methods: In this study, 24 Wistar rats were used. The rats were divided into four groups: 0.9 % NaCl was administered intrathecally to Group 1 (control); esmolol 1 mg to Group 2; 2 mg to Group 3; 4 mg to Group 4 in 10 μL volume each. Tail-flick tests were performed on all groups, before administering drug (0) and at 5, 10, 20, 30, 45, 60 and 90 minutes after drug administration. Motor block was also evaluated at these times. Samples of spinal cord were taken to evaluate neurotoxicity. Results: When compared with the control group there was no difference in tail flick times between group 2 and 3. In the fourth group however the Tail-Flick times at 5, 10 20 and 30 min were significantly longer than in the other groups (p<0.05). Motor block did not developed in either group after IT administration of esmolol. There were no statistically significant histopathological changes and histopathological scores were 0 in each group (p>0.05). Conclusion: In conclusion, this study, in which esmolol was used for the first time intrathecally, shows that 4 mg esmolol provides analgesia for 30 minutes without any motor block or histhopathological toxicity.