Akademik Veri Yönetim Sistemi
Annals of Medical Sciences, cilt.8, sa.2, ss.125-128, 1999 (Scopus)
Purpose: Gastric carcinoids are uncommon, comprising only 5% of all gastrointestinal carcinoids. Some of these tumors present with malignant features and metastasis. There is still contraversy about the terminology, as they are sometimes named as atipical carcinoids, neuroendocrine carcinomas, malignant gastric neuroendocrinomas or malignant carcinoids. We aimed to evaluate if there is any clinicopathologic correlation between them. Methods: Three cases were examined histopathologically with paraffin embedded hematoxylene-eosine stained slides. Immunohistochemistry for NSE, chromogranin-A and EMA have been performed. Results: Three gastric tumors with obvious carcinoid morphology and lymphatic or hepatic metastasis have been observed. All patients were males with a mean age of 58. Tumors were located at the lesser curvature, at the submucosa ranging from 1 to 5 cm. Atypical nuclear features, mitosis and vascular invasion were observed in all cases. For the three cases, AMA was negative, while two cases were chromagranin-A positive and all were NSE positive. Systemic examination and history were unremarkable. Conclusion: Gastric carcinoids are uncommon lesions. The highest proportion of metastatic cases is spordic carcinoids, as in the present cases. Categorisation of cases in different backgrounds may highlight the potential risk for metastasis. For proper biopsy diagnosis immunohistochemisiry is valuable. The detailed description of such cases may help in the identification of histopathologic features associated with metastatic behaviour.