A Bio-Acoustic Levitational (BAL) Assembly Method for Engineering of Multilayered, 3D Brain-Like Constructs, Using Human Embryonic Stem Cell Derived Neuro-Progenitors

Bouyer C., Chen P., GÜVEN S., DEMİRTAŞ T. T., Nieland T. J. F., Padilla F., ...Daha Fazla

Advanced Materials, cilt.28, sa.1, ss.161-167, 2016 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1002/adma.201503916
  • Dergi Adı: Advanced Materials
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.161-167
  • Anahtar Kelimeler: bulk acoustic standing waves, multilayered 3D tissue structures, neural constructs, neural progenitor cells, tissue engineering
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.A bio-acoustic levitational assembly method for engineering of multilayered, 3D brainlike constructs is presented. Acoustic radiation forces are used to levitate neuroprogenitors derived from human embryonic stem cells in 3D multilayered fibrin tissue constructs. The neuro-progenitor cells are subsequently differentiated in neural cells, resulting in a 3D neuronal construct with inter and intralayer neurite elongations.