Designing Organotransition Metal Complexes With N,S-Donor Ligands


Çakmakçı E. S., Subaşı E., Öztürk E.

5th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2022), Ankara, Turkey, 23 - 25 November 2022

  • Publication Type: Conference Paper / Unpublished
  • City: Ankara
  • Country: Turkey
  • Dokuz Eylül University Affiliated: Yes

Abstract

Thiosemicarbazone (TSC) analogs are the most important in the group of ligands containing sulfur donor atoms of

Schiff base ligands, which are known to have versatile coordination modes. Thiosemicarbazone derivatives, which

contain a ring structure in their skeleton, are studied intensively due to their many biological activities such as

antibacterial, antitumor, antifungal and antiviral. The conjugated N–N–S system in thiosemicarbazone scaffolds is

shown as the part responsible for the biological activity [1-3]. It is known that thiosemicarbazones containing these

systems form stable complexes with transition metals such as Co(II), Ni(II), Zn(II) and Pd(II), and it has been

observed in studies that these complexes show biological activities. [4]. In particular, cobalt (II) and palladium (II)

complexes obtained with nitrogen and sulfur donor ligands, which are known to contain active ends, are very

interesting both with their activity and with their bonding patterns [5-6]. It is known that thiosemicarbazones form

divalent compounds such as monomer, dimer and trimer as a result of the reactions of nickel metal salts. In addition,

ligands in these compounds show bi- or monodentate bonding in neutral or anionic form.( [lit]. In this context,

nitrogen and sulfur donor ligands containing active sides and Palladium (II) and Cobalt (II) complexes were

investigated. Within the scope of the study, a new thiosemicarbazone ligand with S and N donors was synthesized,

and Palladium (II) and Cobalt (II) complexes were obtained with the synthesized ligand. The structures of these

synthesized compounds were elucidated by elemental analysis, 1 H-NMR, FT-IR spectroscopy and single crystal X-

ray analysis.