Akademik Veri Yönetim Sistemi
5th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2022), Ankara, Türkiye, 23 - 25 Kasım 2022
Thiosemicarbazone (TSC) analogs are the most important in the group of ligands containing sulfur donor atoms of
Schiff base ligands, which are known to have versatile coordination modes. Thiosemicarbazone derivatives, which
contain a ring structure in their skeleton, are studied intensively due to their many biological activities such as
antibacterial, antitumor, antifungal and antiviral. The conjugated N–N–S system in thiosemicarbazone scaffolds is
shown as the part responsible for the biological activity [1-3]. It is known that thiosemicarbazones containing these
systems form stable complexes with transition metals such as Co(II), Ni(II), Zn(II) and Pd(II), and it has been
observed in studies that these complexes show biological activities. [4]. In particular, cobalt (II) and palladium (II)
complexes obtained with nitrogen and sulfur donor ligands, which are known to contain active ends, are very
interesting both with their activity and with their bonding patterns [5-6]. It is known that thiosemicarbazones form
divalent compounds such as monomer, dimer and trimer as a result of the reactions of nickel metal salts. In addition,
ligands in these compounds show bi- or monodentate bonding in neutral or anionic form.( [lit]. In this context,
nitrogen and sulfur donor ligands containing active sides and Palladium (II) and Cobalt (II) complexes were
investigated. Within the scope of the study, a new thiosemicarbazone ligand with S and N donors was synthesized,
and Palladium (II) and Cobalt (II) complexes were obtained with the synthesized ligand. The structures of these
synthesized compounds were elucidated by elemental analysis, 1 H-NMR, FT-IR spectroscopy and single crystal X-
ray analysis.