Stonin 2 is an endocytic sorting adaptor for synaptotagmin 1
GBM Annual Fall meeting Berlin/Potsdam 2005, Potsdam, Almanya, 01 Eylül 2005, ss.1, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Doi Numarası: 10.1240/sav_gbm_2005_h_001435
- Basıldığı Şehir: Potsdam
- Basıldığı Ülke: Almanya
- Sayfa Sayıları: ss.1
- Dokuz Eylül Üniversitesi Adresli: Hayır
Özet
Clathrin-mediated endocytosis is involved in the internalization, recycling, and degradation of cycling membrane receptors as well as in the biogenesis of synaptic vesicle proteins. While many constitutively internalized cargo proteins are recognized directly by the clathrin adaptor complex AP-2, stimulation-dependent endocytosis of membrane proteins is often facilitated by specialized sorting adaptors. Although clathrin-mediated endocytosis appears to be a major pathway for presynaptic vesicle cycling, no sorting adaptor dedicated to synaptic vesicle membrane protein endocytosis has been indentified in mammals. Here we show that stonin 2, a mammalian ortholog of Drosophila stoned B, facilitates clathrin/ AP-2-dependent internalization of synaptotagmin 1 in living neurons as well as in non-neuronal cells. The ability of stonin 2 to facilitate endocytosis of synaptotagmin is dependent on its association with AP-2, an intact mu-homology domain, and functional AP-2 heterotetramers. Our data identify stonin 2 as an AP-2-dependent endocytic sorting adaptor for synaptotagmin internalization.