Effect of Coenzyme Q(10) on ischemia and neuronal damage in an experimental traumatic brain-injury model in rats


Kalayci M., Unal M. M., GÜL Ş., Acikgoz S., Kandemir N., HANCI V., ...More

BMC NEUROSCIENCE, vol.12, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12
  • Publication Date: 2011
  • Doi Number: 10.1186/1471-2202-12-75
  • Journal Name: BMC NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Dokuz Eylül University Affiliated: No

Abstract

Background: Head trauma is one of the most important clinical issues that not only can be fatal and disabling, requiring long-term treatment and care, but also can cause heavy financial burden. Formation or distribution of free oxygen radicals should be decreased to enable fixing of poor neurological outcomes and to prevent neuronal damage secondary to ischemia after trauma. Coenzyme Q(10) (CoQ(10)), a component of the mitochondrial electron transport chain, is a strong antioxidant that plays a role in membrane stabilization. In this study, the role of CoQ(10) in the treatment of head trauma is researched by analyzing the histopathological and biochemical effects of CoQ(10) administered after experimental traumatic brain injury in rats. A traumatic brain-injury model was created in all rats. Trauma was inflicted on rats by the free fall of an object of 450 g weight from a height of 70 cm on the frontoparietal midline onto a metal disc fixed between the coronal and the lambdoid sutures after a midline incision was carried out.