INFLUENCE OF SEROTONIN ON THE HUMAN URETER - AN IN-VITRO PHARMACOLOGICAL STUDY

GIDENER S., KIRKALI Z., GUVEN H.

UROLOGIA INTERNATIONALIS, vol.55, no.4, pp.202-204, 1995 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 4
  • Publication Date: 1995
  • Doi Number: 10.1159/000282786
  • Journal Name: UROLOGIA INTERNATIONALIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.202-204
  • Keywords: SEROTONIN, 5-HYDROXYTRYPTAMINE RECEPTORS, URETER, HUMAN, SMOOTH MUSCLE
  • Dokuz Eylül University Affiliated: No

Abstract

The influence of serotonin (5-hydroxytryptamine, 5-HT) on human ureteral smooth muscle was explored in a series of in vitro experiments. 5-HT evoked a dose-dependent contraction of the ureter, The effect of 5-HT was unaltered by blockade of 5HT(3) and 5HT(4) receptors and muscarinic cholinergic receptors. The 5HT(2) receptor antagonist ketanserin (KT; 10(-5)-10(-4) M) and mixed 5HT(1)/5HT(2) receptor antagonist methysergide (MS; 5 x 10(-5) M) inhibited the effect of 5-HT. Since the antagonist dissociation constant at 5HT(2) receptors for both KT and MS is found to be approximately 10(-9) M, it is concluded that this contractile effect may have been mediated by some other, as yet uncharacterized 5-HT receptor. We believe that 5-HT is a potential neurotransmitter in the human upper ureteral smooth muscle.