Akademik Veri Yönetim Sistemi
THOD - Turk Hematoloji-Onkoloji Dergisi, cilt.14, sa.3, ss.147-152, 2004 (Scopus)
In recent years, the vascular toxicity of cancer chemotherapy drugs has become more widely subject of interest. Although spesific vascular complications have been described following the administration of particular chemotherapeutic agents, the role 5-FU in the development of vascular complications in cancer patients remains largely speculative. In this study, ten patients with colon cancer receiving infusional 5-FU bimonthly were studied for plasma tissue factor levels by the ELISA method, and test results were compared with the results obtained at baseline period (before 5-FU administration). All patients were diagnosed as stage II or III colon cancer. There was a mild increase of plasma tissue factor levels during the infusional 5-FU chemotherapy (treatment group) compared with baseline levels (control group), but this increase was not statistically significant. Mean plasma TF level of the control group was 36.2+24.2 pg/ml (range 10.3 to 90.5) and treatment group was 49.1±40.5 pg/ml (range 5.4 to 134.1). No thrombotic complications were observed in whole group. Plasma tissue factor may have a role in the development of vascular complications in patients who are receiving infusional 5-FU chemotherapy.