Huge renal cyst with parietal renal cell carcinoma, osseous metaplasia and a papillary adenoma: a case report with unique clinicopathological features and literature review

Puppa G., Gervasio A., YÖRÜKOĞLU K., Colombari R., De Marchi F., Canzonieri V.

VIRCHOWS ARCHIV, vol.452, no.3, pp.325-330, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 452 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1007/s00428-007-0547-8
  • Journal Name: VIRCHOWS ARCHIV
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.325-330
  • Keywords: renal cell carcinoma, cyst, papillary adenoma, osseous metaplasia, FREE-WALL, ADENOCARCINOMA
  • Dokuz Eylül University Affiliated: Yes


The unique clinicopathological features of a giant solitary renal cyst with a parietal clear cell carcinoma in contiguity with a focus of osseous metaplasia and a papillary adenoma are reported. Ultrasonography and computed tomography showed a single cyst with a focal wall irregularity. During surgery, a frozen section revealed the presence of a renal cell carcinoma of clear cell type, so a nephrectomy was performed. After extensive pathological sampling of the cyst's wall, a focus of osseous metaplasia in contiguity with the main tumour and a microscopic papillary adenoma were found. Diagnostic implications for the present case are discussed within a pertinent literature review.