Combined Treatment with Progesterone and Magnesium Sulfate Positively Affects Traumatic Brain Injury in Immature Rats

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UYSAL HARZADIN N., BAYKARA B., KİRAY M., Cetin F., AKSU İ., DAYI A., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.23, sa.2, ss.129-137, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5137/1019-5149.jtn.5582-11.1
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.129-137
  • Anahtar Kelimeler: Traumatic brain injury, Immature rat, Spatial learning and memory, Apoptosis, VEGF, Magnesium sulfate, Progesterone, INDUCED HIPPOCAMPAL DAMAGE, METHYL-D-ASPARTATE, COGNITIVE DYSFUNCTION, NEUROTROPHIC FACTOR, HEAD TRAUMA, CELL-DEATH, MEMORY, CHILDREN, ANTAGONISTS, ACTIVATION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

AIM: It is well known that head trauma results in damage in hippocampal and cortical areas of the brain and impairs cognitive functions. The aim of this study is to explore the neuroprotective effect of combination therapy with magnesium sulphate (MgSO4) and progesterone in the 7-days-old rat pups subjected to contusion injury.