Helicobacter pylori Infection among Children with Phenylketonuria

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ÖZTÜRK Y., Erdur B., Arslansoyu S., Soylar R.

JAPANESE JOURNAL OF INFECTIOUS DISEASES, vol.66, no.5, pp.433-435, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.7883/yoken.66.433
  • Journal Name: JAPANESE JOURNAL OF INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.433-435
  • Dokuz Eylül University Affiliated: Yes

Abstract

This study aimed to determine the frequency of Helicobacter pylori infections in children with phenylketonuria (PKU). Sixty-six children with PKU (35 boys, 31 girls; mean age, 8.2 +/- 6.7 years) and 32 outpatient controls (15 boys, 17 girls; mean age, 9.6 +/- 4.7 years) were studied. Socioeconomic factors did not differ between the two groups. The frequency of H. pylori infections was higher in patients with PKU (28.1%) than in healthy controls (9.4%). In particular, a higher frequency of infection was detected in patients with PKU with poor metabolic control (51.8%). The frequency of H. pylori infection in patients with PKU with good metabolic control was only 10.2%. There was no difference in the mean total WISC-R score between the poor and good metabolic control groups. A high frequency of H. pylori infection in children with PKU with poor metabolic control could be related to many factors. Advanced and standardized clinical studies on H. pylori infections in children with PKU are required.