Akademik Veri Yönetim Sistemi
Klinik Psikofarmakoloji Bulteni, cilt.12, sa.4, ss.179-185, 2002 (Scopus, TRDizin)
Olanzapine, an atypical antipsychotic agent, is used efficiently in adult schizophrenic patients. However studies about olanzapine medication in children and adolescents are significantly infrequent. In this study, efficiency and side effects of olanzapine were discussed. Five subjects with different diagnosis were evaluated in our child and adolescent psychiatry outpatient clinic. The first subject was a 13 years old male, with Tourette's disorder. The second was a 15 years old female, with autistic disorder. The third was a 17 years old male, with bipolar disorder. The fourth was a 12 years old female, with eating disorder NOS. The last one was 10 years old male, with early onset schizophrenia. For all the subjects, the efficiency of olanzapine treatment was evaluated by Clinical Global Impression (CGI). In addition to CGI, Yale Global Tic Severity Scale (YGTSS) and DSM-IV Symptom Checklist by Turgay (DSCT) was used for the assesment of cases 1 and 2, respectively. Olanzapine was medicated at 5-15 mg daily doses. In the first subject 1 point decrement was measured in YGTSS at the end of the 12. week. Then the medication was discontinued due to little clinical improvement. In the second subject 9 point decrement was measured in DSCT at the end of the 12. week. Significant improvement was assessed in CGI for subjects third and fourth, however moderate improvement is assessed in CGI for early onset schizophrenia. Weight gain was observed in patients 2. and 3.; no other significant side effect was observed. Taking into consideration that, despite it's uneffectiveness in Tourette's disorder, it's benefits in clinical improvement for different diagnosis, this paper aims to enlighten the efficacy and the side effect profile of olanzapine in disorders of child and adolescent age group. Olanzapine advantages regarding it's side effects will facilitate planning research on its use in the child and adolescent population for different indications and will ease its use by the clinicians.