An extremely rare case with diagnoses of cerebral amyloid angiopathy, idiopathic normal pressure hydrocephalus, and dementia with Lewy bodies
Electronic Journal of General Medicine, vol.23, no.4, 2026 (ESCI, Scopus)
- Publication Type: Article / Article
- Volume: 23 Issue: 4
- Publication Date: 2026
- Doi Number: 10.29333/ejgm/19178
- Journal Name: Electronic Journal of General Medicine
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
- Keywords: cerebral amyloid angiopathy, cognitive impairment, dementia with Lewy bodies, idiopathic normal pressure hydrocephalus, rapidly cognitive decline
- Open Archive Collection: AVESIS Open Access Collection
- Dokuz Eylül University Affiliated: Yes
Abstract
Introduction: Inflammatory cerebral amyloid angiopathy (iCAA) is an inflammatory condition seen in cerebral amyloid angiopathy (CAA) which is a disease pathologically characterized by β-amyloid deposition in the walls of cortical and leptomeningeal arteries. It contributes independently to cognitive impairment in older adults and is most commonly associated with Alzheimer’s disease (AD). Case reports: We describe a 73 year old male patient presenting with rapidly progressive cognitive decline with clinical dementia syndromes other than AD, namely idiopathic normal pressure hydrocephalus and dementia with Lewy bodies at the same time, who is not widely thought to be related to CAA and thus may have been overlooked. Conclusion: This case is striking to illustrate that inflmmatory CAA may also present in the context of multiple neurodegenerative diseases and interact with them leading to be an independent variable for rapidly progressive decline and immunosupressive treatment may help slow down the cognitive decline and cause improvement in Daily living activities in the life of older adults. It is of importance to diagnose and manage iCAA for the accurate patient care and for research settings.