YMDD motif variants in inactive hepatitis B carriers detected by Inno-Lipa HBV DR assay

AKARSU M., Sengonul A., Tankurt E., SAYINER A. A., Topalak O., AKARSU M., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.21, no.12, pp.1783-1788, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 12
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1440-1746.2006.04567.x
  • Journal Name: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1783-1788
  • Keywords: carrier, hepatitis B virus, inactive, line probe assay (LIPA), YMDD mutation, MONITORING DRUG-RESISTANCE, VIRUS POLYMERASE GENE, LINE PROBE ASSAY, LAMIVUDINE TREATMENT, CLINICAL-SIGNIFICANCE, INFECTED PATIENTS, SURFACE-ANTIGEN, THERAPY, REPLICATION, MUTATIONS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Introduction: Mutations of hepatitis B virus (HBV) polymerase, especially occurring at the highly conserved YMDD region, are related to resistance to lamivudine. Although these mutations are frequently secondary to lamivudine use, they can also occur naturally. The aim of the present study was to determine the prevalence of YMDD variants that exist naturally in patients who are inactive HBV carriers.