Synthesis of ethanone derived from 2-benzoxazolinones and their antimicrobial activities

Erol D., Calis U., Yulug N.

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, vol.46, no.2, pp.205-206, 1996 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 2
  • Publication Date: 1996
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, International Pharmaceutical Abstracts
  • Page Numbers: pp.205-206
  • Keywords: antibacterial agents, antifungal agents, 2-benzoxazolinone, ethanone derivatives, in vitro studies, synthesis
  • Dokuz Eylül University Affiliated: No


A number of 3-(4-substituted benzoyl methyl)-2-benzoxazolinones have been synthesized by reacting with 2-benzoxazolinone and 4-substitutet phenacyl bromide in ethanol. Their structures were confirmed by microanalysis, IR and NMR spectral analysis. Possible antimicrobial activity of the compounds was investigated by tube dilution and paper disc techniques using bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Staphylococcus faecalis RSKK 10541) and yeast-like fungi (Candida parapsilosis, Candida albicans, Candida pseudotropicalis, Candida stellaoidea). Among the compounds tested 3-(4-bromo benzoylmethyl)-5-chloro-2-benzoxazolinone (compound 4) and 3-(4-nitro benzoyl methyl)-5-chloro-2-benzoxazolinone (compound 6) showed the most favorable activity.