Beneficial effects of arginase inhibition and inhaled L-arginine administration on airway histology in a murine model of chronic asthma

Arikan-Ayyildiz Z., Karaman M., Tuncel T., Kiray M., BAĞRIYANIK H. A., Yilmaz O., ...More

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, vol.42, no.4, pp.316-323, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.1016/j.aller.2013.01.001
  • Journal Name: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.316-323
  • Keywords: Asthma, Murine model, L-Arginine, Arginase inhibition, nor-NOHA, NITRIC-OXIDE SYNTHASE, INFLAMMATION, ALLERGEN, HYPERRESPONSIVENESS, SUPEROXIDE, DISEASE, MICE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Increased arginase activity in the airways induces reduced bioavailability of L-arginine and cause deficiency of bronchodilatating and anti-inflammatory nitric oxide (NO). Therefore, arginine and arginase inhibitors may have therapeutic potential in the treatment of asthma. Using a murine model of asthma, we aimed to investigate the effects of inhaled L-arginine and arginase inhibitor N omega-hydroxy-nor-L-arginine (nor-NOHA) and co-treatment on airway histology of asthmatic lung tissue.