Robust Connectivity Scores for Gene Co-Expression Network Analysis

Alin A., Ölmez A.

2021 Virtual International Workshop ​of G.S.I., Samos, Yunanistan, 24 - 26 Eylül 2021, ss.17-25

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Samos
  • Basıldığı Ülke: Yunanistan
  • Sayfa Sayıları: ss.17-25
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

With the advantage of high throughput technologies, gene network analysis became a crucial tool in bioinformatics. Large-scale microarray expression gene network studies explore the identification, functions and relations of individual genes or their products across biological conditions. One of the network-based methods is gene coexpression networks, which are used for describing associations between high-throughput expression patterns of genes. Connectivity scores, calculated using model-based approaches, can be used to build edges in networks. Herein, we introduce new model-based scores that are robust to noise and non-normality in the data.