Scintigraphic imaging with Tc-99m exorphin C in rabbits

Ertay T., ÜNAK P., Tasci C., ZİHNİOĞLU F., Durak H.

APPLIED RADIATION AND ISOTOPES, cilt.62, sa.6, ss.883-888, 2005 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 6
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.apradiso.2004.10.016
  • Dergi Adı: APPLIED RADIATION AND ISOTOPES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.883-888
  • Anahtar Kelimeler: exophin C, Tc-99m-GE, Tc-99m-GH, Tc-99m-labeled peptides, rabbit, scintigraphy
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Exorphin C is a peptide with five amino acids [(Tyr-Pro-Ile-Ser-Leu) Trifluoroacetate salt] (Sigma) that has an affinity to opioid receptor-expressing tissues and tumors. Exorphin-C was labeled with Tc-99m using glucoheptonate (GH) as bifunctional chelating agent. Then, we investigated its radiopharmaccutical potential as opioid receptor-expressing tissue on rabbits.