The evaluation of ventrikular function of newly diagnosed idiopatic generalized epileptic children with tissue Doppler imaging

Yilmaz C., Doksoz O., Unalp A., Mese T., Karaaslan U.

IZMIR DR BEHCET UZ COCUK HASTANESI DERGISI, vol.8, no.1, pp.23-30, 2018 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.5222/buchd.2018.023
  • Journal Name: IZMIR DR BEHCET UZ COCUK HASTANESI DERGISI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.23-30
  • Keywords: Idiopathic epilepsy, diastolic function, tissue Doppler imaging, VENTRICULAR DIASTOLIC DYSFUNCTION, TEMPORAL-LOBE EPILEPSY, CARDIOVASCULAR AUTONOMIC RESPONSES, TACHYCARDIA-INDUCED CARDIOMYOPATHY, P-WAVE DISPERSION, SEIZURES, ECHOCARDIOGRAPHY, SYMPTOMS, HEART, PATHOPHYSIOLOGY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Epileptic discharges spread all over central autonomic area, and may alter normal autonomic control over vital cardiac functions. In our study we aimed to evaluate left ventricular diastolic function of the yet untreated patients with newly diagnosed idiopathic generalized epilepsy using tissue Doppler imaging (TDI).& para;& para;Methods: Thirty-one yet untreated patients aged 1 month-18 years who were newly diagnosed as idiopathic generalized epilepsy based on 1981 ILAE classification were included in the study. Control group consisted of age-, and gender-matched 29 healthy children. Transthoracic two-dimensional and Doppler echocardiographic examinations of the patients were performed.& para;& para;Results: Median age of the cases was 7.42 (3.52) years. There were not significant differences between patients and control groups as assessed with conventional echocardiographic variables (p>0.05). Right ventricular isovolumic contraction times (IVCTs) of the case and control groups were estimated with tissue Doppler imaging, and shorter IVCTs were found in the patient group. A statistically significant difference existed between the patient, and the control groups in terms of IVCT values. Differences between the measurements of systolic peak velocities of the medial wall of the annulus, and also between IVCT values (p<0.05) were significant in case and control groups. More comprehensive studies should be conducted to interpret lower IVCT values regarding systolic dysfunction.& para;& para;Conclusion: In conclusion, diastolic dysfunction was not detected in the patient group, we think that diastolic functions of our patients may not yet altered because of smaller mean age of our newly diagnosed patients with longer time intervals between seizures. Therefore more comprehensive, and long-term studies with greater number of drug- resistant epileptic children should be conducted to show the effect of epilepsy on diastolic function in children.