Hyperglycemia is associated with lower levels of urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor in wound fluid

AKINCI B., Terzi C., Sevindik G., Yuksel F., Tunc U. A., Tunali S., ...More

JOURNAL OF DIABETES AND ITS COMPLICATIONS, vol.28, no.6, pp.844-849, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.1016/j.jdiacomp.2014.07.013
  • Journal Name: JOURNAL OF DIABETES AND ITS COMPLICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.844-849
  • Keywords: Wound healing, Hyperglycemia, Plasminogen activation, Wound fluid, Diabetes, DIABETES IMPAIRS, FIBROBLASTS, MECHANISMS, GENERATION, MORBIDITY, MORTALITY, CELLS, MICE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aims: Wounds in patients with hyperglycemia show impaired healing. Plasminogen activation is crucial in several overlapping phases of wound healing process. In this study, we aimed i) to compare acute wound fluid in patients with hyperglycemia and normoglycemia, ii) to focus on the elements of plasminogen activation in the wound fluid, and iii) to determine if the acute wound fluid characteristics are associated with surgical site infections.