Interleukin-1 receptor antagonist (IL-1RN) and interleukin-1B gene polymorphisms in Turkish patients with rheumatoid arthritis


Arman A., YILMAZ M. B., Coker A., Inanc N., DİRESKENELİ R. H.

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol.24, no.6, pp.643-648, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 6
  • Publication Date: 2006
  • Journal Name: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.643-648
  • Keywords: 1L-1B and IL-1RN polymorphism, rheumatoid arthritis, SYSTEMIC-LUPUS-ERYTHEMATOSUS, DISEASE-ACTIVITY, TANDEM REPEAT, PLASMA-LEVELS, ASSOCIATION, POPULATION, IL-1-BETA, SECRETION, SEVERITY, TURKEY
  • Dokuz Eylül University Affiliated: No

Abstract

Objective Interleukin I (IL-1) family is composed of two agonists, IL-1 alpha and IL-1 beta and IL-1 receptor antagonist, IL-1Ra. The purpose of this study was to determine the relationship between polymorphisms of IL-1 receptor antagonist (IL-1RN), IL-1B promoter and IL-1B exon 5 genes and susceptibility to rheumatoid arthritis (RA) in Turkish population.