Pretreatment with remifentanil protects against the reduced-intestinal contractility related to the ischemia and reperfusion injury in rat

SAYAN ÖZAÇMAK H., Ozacmak V. H., TURAN İ., BARUT F., Hancic V.

REVISTA BRASILEIRA DE ANESTESIOLOGIA, vol.65, no.6, pp.483-490, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.1016/j.bjan.2013.09.006
  • Journal Name: REVISTA BRASILEIRA DE ANESTESIOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.483-490
  • Keywords: Intestinal contractility, Intestinal ischemia/ reperfusion injury, Rat, Remifentanil, OPIOID-RECEPTOR ACTIVATION, K-ATP-CHANNELS, IN-VITRO, ISCHEMIA/REPERFUSION INJURY, INTERSTITIAL-CELLS, L-ARGININE, CARDIOPROTECTION, INFLAMMATION, SEVOFLURANE, MOTILITY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background and objectives: Serious functional and structural alterations of gastrointestinal tract are observed in failure of blood supply, leading to gastrointestinal dismotility. Activation of opioid receptors provides cardioprotective effect against ischemia-reperfusion (i/R) injury. The aim of the present study was to determine whether or not remifentanil could reduce i/R injury of small intestine.