Effects of Inhaled L-Arginine Administration in A Murine Model of Acute Asthma

Arikan-Ayyildiz Z., KARAMAN M., Firinci F., KİRAY M., BAĞRIYANIK H. A., YILMAZ O., ...More

IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, vol.13, no.5, pp.317-323, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 5
  • Publication Date: 2014
  • Journal Name: IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.317-323
  • Keywords: Acute asthma, Inflammation, L-arginine, Murine model, SaO(2), NITRIC-OXIDE SYNTHASE, AIRWAY INFLAMMATION, ARGINASE, ALLERGEN, SUPEROXIDE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Increased arginase activity in the airways decreases L-arginine and causes deficiency of bronchodilating and anti-inflammatory nitric oxide (NO) in asthma. As, it is suggested that Larginine may have therapeutic potential in asthma treatment, we aimed to investigate the effects of inhaled L-arginine on oxygen saturation (SaO(2)) and airway histology in a murine model of acute asthma.