Dyeing fungi: amphotericin B based fluorescent probes for multiplexed imaging
CHEMICAL COMMUNICATIONS, vol.57, no.15, pp.1899-1902, 2021 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 57 Issue: 15
- Publication Date: 2021
- Doi Number: 10.1039/d0cc08177a
- Journal Name: CHEMICAL COMMUNICATIONS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, MEDLINE, DIALNET
- Page Numbers: pp.1899-1902
- Dokuz Eylül University Affiliated: No
Abstract
The clinically used antifungal polyene amphotericin B was conjugated, via the mycosamine and the aglycon moieties, to fluorophores. The Cy5 conjugated probe showed selective labelling of fungi in the presence of bacteria, allowing multiplexed imaging and identification of microbial species in a co-culture of fungi and Gram-positive and Gram-negative bacteria.