Dyeing fungi: amphotericin B based fluorescent probes for multiplexed imaging

Baibek A., ÜÇÜNCÜ M., Short B., Ramage G., Lilienkampf A., Bradley M.

CHEMICAL COMMUNICATIONS, cilt.57, sa.15, ss.1899-1902, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 15
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1039/d0cc08177a
  • Dergi Adı: CHEMICAL COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, MEDLINE, DIALNET
  • Sayfa Sayıları: ss.1899-1902
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

The clinically used antifungal polyene amphotericin B was conjugated, via the mycosamine and the aglycon moieties, to fluorophores. The Cy5 conjugated probe showed selective labelling of fungi in the presence of bacteria, allowing multiplexed imaging and identification of microbial species in a co-culture of fungi and Gram-positive and Gram-negative bacteria.