Association of metallothionein expression and clinical response to cisplatin based chemotherapy in testicular germ cell tumors

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Tuzel E., YÖRÜKOĞLU K., Ozkara E., Kirkali Z.

CENTRAL EUROPEAN JOURNAL OF UROLOGY, cilt.68, sa.1, ss.45-50, 2015 (ESCI, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5173/ceju.2015.01.486
  • Dergi Adı: CENTRAL EUROPEAN JOURNAL OF UROLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.45-50
  • Anahtar Kelimeler: testicular germ cell tumors, metallothionein, cisplatin, immunohistochemistry, chemoresistance
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Introduction The protective roles of metallothioneins (MT) against metal toxicity suggest that MT may have a functional role in cisplatin resistance. The aim of this study was to investigate the expression of MT in specimens of germ cell tumors and compare it with clinical sensitivity to cisplatin based chemotherapy.