Akademik Veri Yönetim Sistemi
Revista Espanola de Cirugia Ortopedica y Traumatologia, cilt.52, sa.1, ss.11-18, 2008 (Scopus)
Aim: The aim of this study is to investigate the effect of systemic (intraperitoneally) two different doses ondansetron administration on analgesic activity of bupivacaine administered intrathecally in rats. Materials and Methods: 24 rats were included in the study. Group Saline (Group S) (n=6): 10 μL of saline was administered intrathecally (IT) and 0.5 mL of saline was administered intraperitoneally. Group Bupivacaine (Group B) (n=6): 10 μg 10 μL-1 of bupivacaine was administered IT and 0.5 mL of saline was administered intraperitoneally. Group Bupivacaine Ondansetron 1 (Group BO1) (n=6): 10 μg 10 μL-1 of bupivacaine was administered IT and 1 mg kg-1 ondansetron was administered intraperitoneally. Group Bupivacaine Ondansetron 4 (Group BO4) (n=6): 10 μg 10 μL-1 of bupivacaine was administered IT and 4 mg kg-1 ondansetron was administered intraperitoneally. Tau-flick test was applied to rats before and 5,10,20,30,45,60,90,120 minutes after drug administration. Data was showed as the percentage of maximum possible effect (%MPE). The presence of simultaneous motor block was evaluated with motor block evaluation scale. Results: Mean tail-flick values of Group B were significantly higher at each time compared to Group S (p<0.05). Mean tail-flick values of Group BO1 were significantly lower compared to Group B (p<0.05). Mean tail-flick values of Group BO4 were also significantly lower than mean tail-flick values of Group B. When mean tail-flick values of Group BO4 art; compared to mean values of Group BOl, mean values of Group BO4 were significantly lower (p<0.05). As a result of motor block evaluation, no motor block was determined in any measurement minutes. Conclusion: This study showed that, the analgesic activity of 10 μL of intrathecal bupivacaine was reduced by 1 mg/kg intraperitoneal ondansetron and this reduction was much more evident with 4 mg/kg-1 intraperitoneal ondansetron.