Intranasal surfactant protein D as neuroprotective rescue in a neonatal rat model of periventricular leukomalacia


KUMRAL A., Iscan B., Engur D., Tuzun F., ÖZBAL S., Ergur B. U., ...More

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, vol.30, no.4, pp.446-451, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.1080/14767058.2016.1174996
  • Journal Name: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.446-451
  • Keywords: Nasal drug delivery, newborn, periventricular leukomalacia, surfactant protein D, ISCHEMIC BRAIN-INJURY, WHITE-MATTER INJURY, NF-KAPPA-B, PULMONARY SURFACTANT, LIPOPOLYSACCHARIDE, DELIVERY, INFLAMMATION, MOLECULES, PATHWAYS, INSULIN
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Periventricular leukomalacia (PVL) is the leading cause of neurocognitive deficits in children with prematurity. We previously hypothesized that surfactant protein D (SPD) with its ability to bind toll-like receptors may have a possible ameliorating effect in PVL.