Intranasal surfactant protein D as neuroprotective rescue in a neonatal rat model of periventricular leukomalacia

KUMRAL A., Iscan B., Engur D., Tuzun F., ÖZBAL S., Ergur B. U., ...Daha Fazla

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.30, sa.4, ss.446-451, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/14767058.2016.1174996
  • Dergi Adı: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.446-451
  • Anahtar Kelimeler: Nasal drug delivery, newborn, periventricular leukomalacia, surfactant protein D, ISCHEMIC BRAIN-INJURY, WHITE-MATTER INJURY, NF-KAPPA-B, PULMONARY SURFACTANT, LIPOPOLYSACCHARIDE, DELIVERY, INFLAMMATION, MOLECULES, PATHWAYS, INSULIN
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Periventricular leukomalacia (PVL) is the leading cause of neurocognitive deficits in children with prematurity. We previously hypothesized that surfactant protein D (SPD) with its ability to bind toll-like receptors may have a possible ameliorating effect in PVL.