Akademik Veri Yönetim Sistemi
Turk Kardiyoloji Dernegi Arsivi, cilt.31, sa.4, ss.198-203, 2003 (Scopus, TRDizin)
In this study, the relationship was evaluated between Flow-Mediated Dilation (FMD) and Nitrate-Induced Dilation (NID) of brachial artery and severity of coronary artery disease. Study group was consisted of 64 patients with angina pectoris who had established coronary artery disease documented by coronary angiography (Group I), 12 patients who had normal coronary arteries with abnormal exercise test (Group II) and 18 healthy subjects who had normal exercise test. FMD and NID were calculated as the percent change in diameter compared to baseline of brachial artery. According the angiographic findings, Group I patients were divided into two subgroups as single or multi vessel disease. Results were compared among the groups. FMD was significantly lower in Group I and II than Group III (p<0.001). NID was significantly higher in Group II and III than Group I (p<0.001). FMD was not different between Group I and II (p>0.05); however NID was significantly higher in Group II than Group I (p<0.001). In Group I, 16 patients had single vessel and 48 patients had multi vessel disease. Although NID was not different between these subgroups (p>0.05), FMD was significantly higher in patients who had multi vessel disease than single vessel (p<0.001). Abnormal FMD of the brachial artery is related to severity of coronary artery disease and it may be a marker for progressive course of the disease. Normal NID of the brachial artery suggests that possible deficiency in the endogenous nitric oxide activities in patients with angiographically normal coronary arteries and abnormal exercise test.