The relationship between renal P-glycoprotein expression and response to steroid therapy in childhood nephrotic syndrome
TURKISH JOURNAL OF PEDIATRICS, vol.55, no.3, pp.260-265, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 55 Issue: 3
- Publication Date: 2013
- Journal Name: TURKISH JOURNAL OF PEDIATRICS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.260-265
- Keywords: renal P-glycoprotein expression, nephrotic syndrome, response to steroid
- Dokuz Eylül University Affiliated: Yes
Abstract
In this study, we aimed to investigate the relationship between renal P-glycoprotein (rP-gp) expression and response to corticosteroid therapy in childhood nephrotic syndrome (NS). Expression of rP-gp was evaluated prior to non-steroid immunosuppressive therapy in children with NS (Group 1), prior to any treatment in children with immunoglobulin (Ig) A nephropathy (Group 2), and during renal donation in healthy adults (Group 3); mesangial proliferation was evaluated in Groups 1 and 2. Total dosage of steroid was calculated in Group 1. The ratio of rP-gp (+) glomeruli was higher in Group 1 than Group 3 (33.8 +/- 27.1% vs 4.7 +/- 4.6%, p= 0.000). There were no rP-gp (+) glomeruli in Group 2. The rate of mesangial proliferation was similar in Groups 1 and 2. There was no statistically significant correlation between rP-gp expression and total steroid dosage (r = 0.455, p = 0.160). Our findings showed that rP-gp expression is increased in patients receiving steroid therapy for NS regardless of the cumulative steroid dosage and mesangial cell proliferation.