Adult-onset still's disease, an unusual cause of severe acute liver injury: A case report

ADIYAMAN S. C., Bengi G., Civak M., Birlik M., Kuruuzum Z., Altay C., ...More

NIGERIAN JOURNAL OF CLINICAL PRACTICE, no.4, pp.581-585, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2020
  • Doi Number: 10.4103/njcp.njcp_1_19
  • Journal Name: NIGERIAN JOURNAL OF CLINICAL PRACTICE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.581-585
  • Keywords: Acute liver failure, acute liver injury, adult-onset Still's disease, fever of unknown origin, immunosuppressive treatment, MANIFESTATIONS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Adult-onset Still's disease is a systemic inflammatory disease that often presents with spiking fever, typical rash, arthritis, and serositis. However, adult-onset-Still's-disease associated liver injury and acute liver failure are rare. Herein, we report a case of acute liver injury in a 23-year-old female patient with adult-onset Still's disease. She presented to the emergency department with a high fever and sore throat. She was then admitted to the department of infectious diseases with a preliminary diagnosis of an atypical respiratory infection. After being treated with antibiotics and antiviral agents, she was discharged. A few days later, she returned to the emergency department with jaundice and was rehospitalized. This time, she was admitted to the department of gastroenterology, where she was diagnosed with adult-onset Still's disease-associated acute liver injury. Eventually, the patient responded to immunosuppressive treatment with significant clinical improvement.