Fetuin-A is related to syndesmophytes in patients with ankylosing spondylitis: a case control study
CLINICS, cilt.69, sa.10, ss.688-693, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 69 Sayı: 10
- Basım Tarihi: 2014
- Doi Numarası: 10.6061/clinics/2014(10)07
- Dergi Adı: CLINICS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.688-693
- Anahtar Kelimeler: Ankylosing Spondylitis, Bone Formation, Fetuin-A, Dickkopf-1 Protein Human, Sclerostin Protein Human, Bone Morphogenetic Protein 7
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
OBJECTIVES: New bone formation is one of the hallmark characteristics of ankylosing spondylitis, which is thereby associated with syndesmophytes. Fetuin-A is a molecule that is abundantly found in calcified tissues and it shows high affinity for calcium phosphate minerals and related compounds. Considering the role of fetuin-A in the regulation of calcified matrix metabolism, we compared the fetuin-A levels in ankylosing spondylitis patients with syndesmophytes with those in patients without syndesmophytes and in healthy controls. We also studied other biomarkers that are thought to be related to syndesmophytes.