Fetuin-A is related to syndesmophytes in patients with ankylosing spondylitis: a case control study

Tuylu T., SARI İ., Solmaz D., Kozaci D. L., Akar S., Gunay N., ...Daha Fazla

CLINICS, cilt.69, sa.10, ss.688-693, 2014 (SCI-Expanded, Scopus) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Sayı: 10
  • Basım Tarihi: 2014
  • Doi Numarası: 10.6061/clinics/2014(10)07
  • Dergi Adı: CLINICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.688-693
  • Anahtar Kelimeler: Ankylosing Spondylitis, Bone Formation, Fetuin-A, Dickkopf-1 Protein Human, Sclerostin Protein Human, Bone Morphogenetic Protein 7
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

OBJECTIVES: New bone formation is one of the hallmark characteristics of ankylosing spondylitis, which is thereby associated with syndesmophytes. Fetuin-A is a molecule that is abundantly found in calcified tissues and it shows high affinity for calcium phosphate minerals and related compounds. Considering the role of fetuin-A in the regulation of calcified matrix metabolism, we compared the fetuin-A levels in ankylosing spondylitis patients with syndesmophytes with those in patients without syndesmophytes and in healthy controls. We also studied other biomarkers that are thought to be related to syndesmophytes.