Fetuin-A is related to syndesmophytes in patients with ankylosing spondylitis: a case control study

Tuylu T., SARI İ., Solmaz D., Kozaci D. L., Akar S., Gunay N., ...More

CLINICS, vol.69, no.10, pp.688-693, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 10
  • Publication Date: 2014
  • Doi Number: 10.6061/clinics/2014(10)07
  • Journal Name: CLINICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.688-693
  • Keywords: Ankylosing Spondylitis, Bone Formation, Fetuin-A, Dickkopf-1 Protein Human, Sclerostin Protein Human, Bone Morphogenetic Protein 7, BONE MORPHOGENETIC PROTEINS, RADIOGRAPHIC PROGRESSION, DISEASE-ACTIVITY, INDEX, BATH, ASSOCIATION, DICKKOPF-1, DAMAGE, LEVEL, DKK-1
  • Dokuz Eylül University Affiliated: Yes

Abstract

OBJECTIVES: New bone formation is one of the hallmark characteristics of ankylosing spondylitis, which is thereby associated with syndesmophytes. Fetuin-A is a molecule that is abundantly found in calcified tissues and it shows high affinity for calcium phosphate minerals and related compounds. Considering the role of fetuin-A in the regulation of calcified matrix metabolism, we compared the fetuin-A levels in ankylosing spondylitis patients with syndesmophytes with those in patients without syndesmophytes and in healthy controls. We also studied other biomarkers that are thought to be related to syndesmophytes.