Fetuin-A is related to syndesmophytes in patients with ankylosing spondylitis: a case control study
CLINICS, vol.69, no.10, pp.688-693, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 69 Issue: 10
- Publication Date: 2014
- Doi Number: 10.6061/clinics/2014(10)07
- Journal Name: CLINICS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.688-693
- Keywords: Ankylosing Spondylitis, Bone Formation, Fetuin-A, Dickkopf-1 Protein Human, Sclerostin Protein Human, Bone Morphogenetic Protein 7
- Dokuz Eylül University Affiliated: Yes
Abstract
OBJECTIVES: New bone formation is one of the hallmark characteristics of ankylosing spondylitis, which is thereby associated with syndesmophytes. Fetuin-A is a molecule that is abundantly found in calcified tissues and it shows high affinity for calcium phosphate minerals and related compounds. Considering the role of fetuin-A in the regulation of calcified matrix metabolism, we compared the fetuin-A levels in ankylosing spondylitis patients with syndesmophytes with those in patients without syndesmophytes and in healthy controls. We also studied other biomarkers that are thought to be related to syndesmophytes.