Prenatal karyotype results of fetuses with nuchal edema, cystic hygroma, and non-immune hydrops

Gezer C., Ekin A., Gezer N. S., Ertas I. E., Avci M. E., Uyar I., ...Daha Fazla

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, cilt.42, sa.5, ss.586-589, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.12891/ceog1889.2015
  • Dergi Adı: CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.586-589
  • Anahtar Kelimeler: Nuchal edema, Cystic hygroma, Non-immune hydrops, Chromosome abnormalities, CHROMOSOMAL-ABNORMALITIES, 1ST TRIMESTER, TRANSLUCENCY THICKNESS, 2ND TRIMESTER, DOWN-SYNDROME, DIAGNOSIS, 1ST-TRIMESTER, PROGNOSIS, FETALIS, PARVOVIRUS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: Subcutaneous edema detected sonographically in the forms of nuchal edema, cystic hygroma (CH), or non-immune hydrops (NIH) may be a sign of chromosomal abnormalities. The aim of this study was to investigate the chromosome abnormality incidence in fetuses with nuchal edema, CH, or NIH. Materials and Methods: The authors performed cytogenetic analysis of 218 singleton fetuses with ultrasound diagnosis of subcutaneous edema in the forms of nuchal edema in the first and second trimesters. Results: Chromosomal abnormality rates were 30.4, 10.4, 36.8, 34.1, and 60% in the nuchal translucency (NT), nuchal fold thickness (NF), CH, NIH, and CH with NIH groups, respectively. In 71 cases with detected chromosomal abnormalities, 37%, 44%, 15%, and 4% of the pathologic karyotypes were identified as monosomy X, trisomy 21, trisomy 18, and trisomy 13, respectively. Conclusions: This study confirms that subcutaneous edema detected sonographically, in the forms of nuchal edema, CH, or NIH, is a significant indicator of abnormal karyotype and deserves further investigation.