Biocompatible and Biodegradable Alginate/Poly(N-isopropylacrylamide) Hydrogels for Sustained Theophylline Release

Dumitriu R. P., Oprea A., YILMAZ C. N., Nistor M., Novac O., Ghiciuc C. M., ...Daha Fazla

JOURNAL OF APPLIED POLYMER SCIENCE, cilt.131, sa.17, ss.8939-8954, 2014 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 131 Sayı: 17
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1002/app.40733
  • Dergi Adı: JOURNAL OF APPLIED POLYMER SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.8939-8954
  • Anahtar Kelimeler: drug delivery systems, polysaccharides, stimuli-sensitive polymers
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Mixed-interpenetrated polymeric networks based on sodium alginate (ALG) and poly(N-isopropylacryl amide) (PNI-PAAm) covalently cross-linked with N,N'-methylenebisacrylamide are studied for their biocompatibility, nontoxicity, and biodegradability aiming their application in drug delivery. The presence of drug-polymeric matrix interactions and the distribution of the drug in the polymeric network for theophylline-loaded ALG/PNIPAAm hydrogels are also investigated by spectroscopic and microscopic methods. The quantitative evaluation of theophylline loaded hydrogels performed by NIR-CI technique shows a better drug entrapment and a higher homogeneity of the samples with increased alginate content. The thermal behavior of the hydrogels is significantly modified by theophylline presence. The application of the ALG/PNIPAAm hydrogels as carriers for sustained drug release formulations was assessed by the theophylline release tests performed both by in vitro and in vivo studies. (C) 2014 Wiley Periodicals, Inc.