Pulmonary hemorrhage after rhDNase treatment in a preterm infant with chronic lung disease

Tatli M. M., KUMRAL A., DUMAN N., Yesilirmak D., ÖZKAN H.

International Pediatrics, vol.19, no.4, pp.234-236, 2004 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2004
  • Journal Name: International Pediatrics
  • Journal Indexes: Scopus
  • Page Numbers: pp.234-236
  • Keywords: Chronic lung disease, Preterm, Pulmonary hemorrhage, rhDNase
  • Dokuz Eylül University Affiliated: Yes


Pulmonary secretions and mucus plugging are common problems in Neonatal Intensive Care Unit (NICU) patients, especially in those with chronic lung disease. Standard methods are not always helpful in resolving these secretions. Because the viscoelastic features of pulmonary secretions are largely due to deoxyribonucleic acid (DNA) content of mucus, a new mucolytic agent used in cystic fibrosis (CF), rhDNase, is proposed for rescue use in premature neonates. We report a premature infant with chronic lung disease, who had pulmonary obstruction secondary to mucus plugging. Lung hemorrhage developed during rhDNase therapy, which was used after standard methods were depleted.