Neuroanatomical correlates of genetic risk for bipolar disorder: A voxel-based morphometry study in bipolar type I patients and healthy first degree relatives

Saricicek, Aybala; Yalin, Nefize; HIDIROĞLU ONGUN, CEREN; Cavusoglu, Berrin; TAŞ, CUMHUR; Ceylan, Deniz; Zorlu, Nabi; ADA, EMEL; Tunca, Zeliha; Ozerdem, Aysegul

doi:10.1016/j.jad.2015.06.055

Neuroanatomical correlates of genetic risk for bipolar disorder: A voxel-based morphometry study in bipolar type I patients and healthy first degree relatives

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Saricicek A., Yalin N., HIDIROĞLU ONGUN C., Cavusoglu B., TAŞ C., Ceylan D., ...More

JOURNAL OF AFFECTIVE DISORDERS, vol.186, pp.110-118, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 186
Publication Date: 2015
Doi Number: 10.1016/j.jad.2015.06.055
Journal Name: JOURNAL OF AFFECTIVE DISORDERS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
Page Numbers: pp.110-118
Keywords: Bipolar disorder, Voxel based morphometry, Endophenotype, Inferior frontal gyrus, Cerebellum, GRAY-MATTER VOLUME, INFERIOR FRONTAL GYRUS, BRAIN STRUCTURAL-CHANGES, PARAHIPPOCAMPAL CORTEX, RESPONSE-INHIBITION, LITHIUM TREATMENT, MRI ANALYSIS, ABNORMALITIES, SCHIZOPHRENIA, MEMORY
Dokuz Eylül University Affiliated: Yes

Abstract

Background: Bipolar disorder (BD) is a highly heritable mental illness which is associated with neuroanatomical abnormalities. Investigating healthy individuals at high genetic risk for bipolar disorder may help to identify neuroanatomical markers of risk and resilience without the confounding effects of burden of illness or medication.