The Impact of Secondary Catheter-Related Bloodstream Infection on the Course of COVID-19 Infection

Nadir Y., Kiran P., Erturk D., Uzun U., Yavuz T., Ersan G., ...Daha Fazla

INFECTIOUS DISEASES IN CLINICAL PRACTICE, cilt.22, sa.2, ss.22, 2024 (ESCI)

Özet

Abstract Background Secondary bacterial infections can worsen the prognosis for COVID-19, especially in patients with severe infections. Thus, we aim to investigate the effect of secondary catheter-related bloodstream infections on the course of COVID-19 infection. Material and Methods This is a retrospective, nested case-control study and included 236 confirmed COVID-19 infection hospitalized patients, divided into 2 groups (COVID-19, n = 64; non–COVID-19, n = 172) according to SARS-CoV-2 RT-PCR results. Results The age, sex, and prevalence of chronic diseases were similar in both groups. Klebsiella pneumoniae (31.2%) and Acinetobacter baumannii (21.9%) were the predominant microorganisms in the COVID-19 group. Only A. baumannii was statistically higher in the COVID-19 group (P = 0.046). There were no significant differences in terms of resistance profiles. The 30-day mortality was significantly higher in the COVID-19 group (56.3%) than in the non–COVID-19 group (38.4%) (P = 0.014). There was no significant difference in the length of stay between the 2 groups. The multiple logistic regression analysis of risk factors for 30-day mortality revealed that COVID-19 positivity (odds ratio [OR], 2.167; 95% confidence interval [CI], 1.056–4.446; P = 0.035), infection with extensively drug-resistant bacteria (OR, 2.949; 95% CI, 1.311–6.636; P = 0.009), and infection with pandrug-resistant bacteria (OR, 3.601; 95% CI, 1.213–10.689; P = 0.021) were independent risk factors for 30-day mortality. Conclusion As a conclusion, this study demonstrated that COVID-19 positivity is an independent risk factor for 30-day mortality of secondary catheter-related bloodstream infections. Gram-negative bacteria were the predominant microorganisms, with A. baumannii being statistically higher in the COVID-19 group compared with the non–COVID-19 group. However, there were no statistically significant differences in terms of the resistance profile of microorganisms.