Effect of Mesenchymal Stem Cells on Cochlear Cell Viability After Cisplatin Induced Ototoxicity

Erçetin A. P., Olgun Y., Aktaş S., Aydin M., Evin Eskicioğlu H., Altun Z. S., ...More

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, vol.4, no.3, pp.378-383, 2020 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.30621/jbachs.2020.1305
  • Journal Name: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.378-383
  • Keywords: mesenchymal stem cells, cochlear cells, cisplatin ototoxicity, MECHANISMS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aims: Ototoxicity is one of the main side effects of the chemotherapeutic agent Cisplatin (CDDP). CDDP ototoxicity is caused by damage of the organ of Corti, spiral ganglion cells or lateral wall (stria vascularis and spiral ligament). Mesenchymal stem cells (MSCs) were shown to differentiate into neurogenic and auditory hair cells in vitro. In this study, effect of MSCs in CDDP ototoxicity model of HEI-OC1 cochlear cells was evaluated.