Prognostic Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for Patients with Neuroendocrine Tumors: An Izmir Oncology Group Study

Salman T., KAZAZ S. N., Varol U., Oflazoglu U., ÜNEK İ. T., KÜÇÜKZEYBEK Y., ...Daha Fazla

CHEMOTHERAPY, cilt.61, sa.6, ss.281-286, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1159/000445045
  • Dergi Adı: CHEMOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.281-286
  • Anahtar Kelimeler: Neuroendocrine tumors, Neutrophil-lymphocyte ratio, Platelet-lymphocyte ratio, CARCINOID-TUMORS, CELLS, INFLAMMATION, RESECTION, SURVIVAL
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Several studies evaluating the prognostic factors of gastrointestinal and pancreatic neuroendocrine tumors (GEP-NETs) have been published. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have been accepted as prognostic factors for cancer patients. Materials and Methods: This study included 132 patients diagnosed with GEP-NETs. Peripheral blood samples were collected before the pretreatment period. Results: NLR and PLR were increased as the grade increased in NETs. The embryonic origin analysis revealed higher NLR and PLR rates in NETs of foregut origin. NLR and PLR were also higher in pancreatic NET patients compared to the gastroenteric NET patients. Analysis of NETs by TNM indicated that an advanced stage was accompanied by significantly higher NLR and PLR. We found a strong negative correlation between progression-free survival and NLR and PLR. Conclusion: The study verified that NLR and PLR are simple laboratory findings that can be used to identify NETs with a worse outcome. (C) 2016 S. Karger AG, Basel.