Study for the diagnostic screening of paroxsymal nocturnal hemoglobinuria in Turkey: Prospective multicentric evaluation of suspected patients

İLHAN, OSMAN; Ozdemir, Zehra; Ozet, Gulsum; Falay, Mesude; YENEREL, Mustafa; Tuglular, Tulin; Turgut, Mehmet; Guvenc, Birol; Unal, Ali; Ayyildiz, Orhan; Andic, Neslihan; Hacihanefioglu, Abdullah; Sahin, Fahri; Sencan, Mehmet; Ali, Ridvan; Ozsan, GÜNER; Yildirim, Rahsan; Tiftik, Eyup; Tombak, Aml; Salim, Ozan; Kaya, Emin; Akay, Olga; Okan, Vahap; Pehlivan, Mustafa; Saydam, Guray

doi:10.1016/j.transci.2019.08.021

Study for the diagnostic screening of paroxsymal nocturnal hemoglobinuria in Turkey: Prospective multicentric evaluation of suspected patients

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İLHAN O., Ozdemir Z. N., Ozet G., Falay M., YENEREL M. N., Tuglular T., ...More

TRANSFUSION AND APHERESIS SCIENCE, vol.58, no.5, pp.659-662, 2019 (SCI-Expanded)

Publication Type: Article / Article
Volume: 58 Issue: 5
Publication Date: 2019
Doi Number: 10.1016/j.transci.2019.08.021
Journal Name: TRANSFUSION AND APHERESIS SCIENCE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.659-662
Keywords: Paroxysmal nocturnal hemoglobinuria, Multiparameter flow cytometry, Diagnostic screening, SOMATIC MUTATION, PNH, COMPLEMENT, GUIDELINES, MANAGEMENT
Dokuz Eylül University Affiliated: Yes

Abstract

Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease presenting with variable and various clinical findings. PNH might be overlooked and diagnosis may be delayed due to low awareness about PNH. This is the first multicenter study in Turkey, investigating the efficiency of diagnostic screening of PNH by multiparameter flow cytometry (FCM) according to consensus guidelines.