Effects of Body Temperature Lowering on Visual Evoked Potentials in Patients with Multiple Sclerosis
TURKISH JOURNAL OF NEUROLOGY, vol.27, no.1, pp.34-40, 2021 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 27 Issue: 1
- Publication Date: 2021
- Doi Number: 10.4274/tnd.2020.25589
- Journal Name: TURKISH JOURNAL OF NEUROLOGY
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
- Page Numbers: pp.34-40
- Keywords: Multiple sclerosis, visual evoked potentials, cooling effect, Uhthoffs phenomenon
- Open Archive Collection: AVESIS Open Access Collection
- Dokuz Eylül University Affiliated: Yes
Abstract
Objective: Aggravation of neurologic symptoms in patients with multiple sclerosis (MS) due to heating is well known. This phenomenon, known as Uhthoff phenomenon (UP), is explained by transient conduction block in demyelinated nerve fibers and transected axons. The threshold of conduction block dependent on temperature is probably proportional to the degree of demyelination or axonal injury. On the other hand, about half of all patients reported improvement in a cold bath (anti-UP effect). This study aimed to assess the effects of body cooling on clinical parameters lneuro-opthalmologic examination and contrast sensitivity in visual acuity/Sloan letter rest, and the Expanded Disability Status Scale (EDSS)] and electrophysiologic measurements [visual evoked potentials (VEP)] in patients with MS previously clinically affected by optic neuritis.