The Protective Effect of The Interleukin 1 Receptor Antagonist on Chronic Thromboembolic Pulmonary Hypertension Model

Kalemci S., Zeybek A., CİLAKER MIÇILI S., Sarihan A., Calisir M., Simsek A., ...More

POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, vol.73, pp.944-950, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 73
  • Publication Date: 2019
  • Doi Number: 10.5604/01.3001.0013.7878
  • Journal Name: POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.944-950
  • Keywords: pulmonary hypertension, pulmonary endarterectomy, interleukin-1 receptor antagonist, chronic pulmonary thromboembolism, pulmonary arteriopathy, RISK-FACTORS, INFLAMMATION, PATHOLOGY, BLOCKING, BONE, IL-1
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aim: Chronic thromboembolic pulmonary hypertension (CTEPH) is one of the main reasons of severe pulmonary hypertension and has significantly higher morbidity and mortality rates. The pathogenesis of the disease is characterized by the incomplete resolution of acute embolisms. The elevated inflammatory conditions after the acute embolism are one of the critical factors. Therefore, we aimed to investigate whether or not anakinra is an option for treating CTEPH in an animal model.