Choroidal Thickness Changes in Rheumatoid Arthritis and the Effects of Short-term Hydroxychloroquine Treatment


Karti O., AYHAN Z., Zengin M. O., KAYA M., Kusbeci T.

OCULAR IMMUNOLOGY AND INFLAMMATION, vol.26, no.5, pp.770-775, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 5
  • Publication Date: 2018
  • Doi Number: 10.1080/09273948.2017.1278777
  • Journal Name: OCULAR IMMUNOLOGY AND INFLAMMATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.770-775
  • Keywords: Choroidal thickness, enhanced depth imaging, hydroxychloroquine, optical coherence tomography, rheumatoid arthritiss, OPTICAL COHERENCE TOMOGRAPHY, HEALTHY JAPANESE SUBJECTS, RHEUMATOLOGY/EUROPEAN LEAGUE, CLASSIFICATION CRITERIA, ENDOTHELIAL DYSFUNCTION, AMERICAN-COLLEGE, DISEASE-ACTIVITY, BLOOD-FLOW, CYTOKINES, ARTERY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Purpose: The objective of this study is to evaluate choroidal thickness (CT) in patients with rheumatoid artritis (RA) and the effects of short-term hydroxychloroquine (HCQ) treatment.Methods: Thirty RA patients (group 1) and 30 normal subjects (group 2) were enrolled in the study. Group 1 was further divided into two subgroups as follows: group 1A (Before HCQ treatment) and group 1B (1 year after HCQ treatment). The CTs were measured using optical coherence tomography (EDI-OCT).Results: The mean subfoveal choroidal thickness (SFCT) (mu m) was 335.70 64.58 in group 1A, 341.85 +/- 63.95 in group 1B, and 358.51 +/- 63.83 in group 2. SFCT was significantly lower in groups 1A and 1B than in group 2 (p = 0.020 and p = 0.028, respectively). Group 1B presented statistically significant thicker SFCT than group 1A (p = 0.033).Conclusions: CT was significantly lower in RA patients than in normal subjects. HCQ treatment may, however, cause a statistically significant increase in SFCT. This increase is clinically negligible.