Aim: Systemic sclerosis-scleroderma (SSc) is an autoimmune collagen disease characterized by skin fibrosis, angiopathy and immune disorders. Although the exact mechanism of the pathogenesis of SSc remains unclear, it is known that its development based on an immune response effecting the vascular system, internal organs and skin with excessive fibrosis and degradation of connective tissue. Depending on the type of the affected organ, different specialties are involved, including dermatology, rheumatology, gastroenterology, cardiology, nephrology and dentistry. Related to the fibrosis of the skin, different orofacial changes are observed, especially restricted mouth opening. Following Rheumatoid arthritis, Sjogren’s syndrome is the second most common autoimmune disease associated with SSc. Case report: Extraoral examination of the patient revealed a restriction in the mouth opening, a reduced lower and upper lip and wrinkles were detected around the mouth. Dry mouth, gingival recessions, cervical lesions and poor plaque control due to limited mouth opening were present intraorally. Probing depth, clinical attachment level, bleeding on probing, plaque index, gingival index, level of gingival recession were recorded. Following clinical and radiographic evaluation, Stage III/Grade B generalized periodontitis was diagnosed and widening of the periodontal ligament was detected in all dentition. First-step in periodontal therapy (scaling and oral hygiene instruction) was performed. Conclusion: Oral health status should be carefully evaluated in patients with SSc and Sjogren's syndrome. It is important to contribute to the regulation of the systemic immune response by reducing the bacterial load in the mouth with periodontal treatment. As a multidiciplinary approach, reduction of oral bacterial and local inflammatory burden through periodontal treatment could be a recommended way to control impaired systemic immune response.