The effects of chronic hepatitis C and B virus infections on liver reduced and oxidized glutathione concentrations

Tanyalcin T., TAŞKIRAN D., Topalak Ö. S., Batur Y., Kutay F.

HEPATOLOGY RESEARCH, cilt.18, sa.2, ss.104-109, 2000 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 2
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1016/s1386-6346(99)00088-1
  • Dergi Adı: HEPATOLOGY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.104-109
  • Anahtar Kelimeler: glutathione, chronic hepatitis, viral hepatitis, liver
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The aim of this study was to evaluate the effects of hepatitis B and C virus infections on liver glutathione status. Reduced and oxidized glutathione levels were determined in liver biopsy specimens obtained from patients with chronic liver disease including chronic active hepatitis and cirrhosis. In patients with hepatitis B virus infections, GSH and GSH/GSSG levels were significantly low compared with those in controls (P < 0.01). There was a significant negative correlation between histological activity indices (HAI) and hepatic GSSG levels only in patients with chronic HCV infection (P < 0.01; r = -0.895). In addition to this, we also found a positive correlation between indices (HAI) and GSPI/GSSG of the same group (r = 0.915; P < 0.05). These observations suggest that HBV and HCV infections have different effects on liver glutathione status based on diverse mechanisms. (C) 2000 Elsevier Science Ireland Ltd, All rights reserved.